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ENDOMETRIO

ENDOMETRIO (ERA +ALICE+EMMA)
Comprehensive examination of the functional state of the endometrium to assess the reproductive prognosis.

Analysis of endometrial receptivity, chronic endometritis and endometrial microflora, including ERA, ALICE, EMMA studies.

Показання до проведення:

Indications for ERA
ERA is indicated for patients with repeated failed implantation attempts, as they have a higher risk of implantation window displacement.
The purpose of this test is to provide an objective molecular diagnosis of the implantation ability and reproductive health of the patient's endometrium.

Indications for ALICE
ALICE can be useful for every patient who wants to get pregnant, as it provides an opportunity to assess the microbiological environment that the embryo will encounter during implantation.
ALICE is also recommended for patients with a history of recurrent pregnancy loss and/or repeated implantation failure, as this can cause chronic endometritis.

Indications for EMMA
EMMA is a molecular test that provides information about the microbiota in the endometrial tissue by analyzing a special panel of bacteria, including information about the most common lactobacillus species and potentially pathogenic bacteria of the reproductive tract (some of which are associated with chronic endometritis). This method is based on the detection of bacterial DNA using real-time PCR (real-time polymerase chain reaction).

Переваги:

Diagnosis of the implantation window period

ERA is an analysis of endometrial receptivity to determine the optimal time for embryo transfer (implantation window period).
ERA can increase the chances of pregnancy by synchronizing the implantation-ready embryo with a receptive endometrium.
This test uses next-generation sequencing (NGS) technology to analyze the expression of 248 genes related to endometrial receptivity.

Diagnosis of infectious chronic endometritis

ALICE is an analysis of infectious chronic endometritis that detects the most common bacteria that cause chronic endometritis.

Chronic endometritis is a persistent inflammation of the endometrial mucosa caused by infection of the uterine cavity, mainly by bacterial pathogens. Chronic endometritis is usually asymptomatic, and modern classical diagnostic methods (histology, hysteroscopy, and microbiological culture) are insufficient to establish a diagnosis.

Diagnosis of Chronic Endometritis and Endometrial Microflora

EMMA - analysis of chronic endometritis and endometrial microflora.
Metagenomic analysis of the endometrial microbiome provides a comprehensive view of the bacterial composition of the endometrium, including pathogens that cause chronic endometritis.
Identification of pathogenic microbiomes may be the key to improving the results of further treatment of chronic endometritis.
Studies have revealed the existence of the endometrial microbiome and demonstrated that uterine dysbiosis is associated with unsuccessful reproductive outcomes. This suggests that pathogenic changes in the level of endometrial lactobacilli may play a role in the development of infertility.
EMMA will help determine whether the microbial environment of the uterus is optimal for embryo implantation.

Preparation and/or course of the procedure

A single biopsy is sufficient for a comprehensive ENDOMETRIO test.

Features and interesting facts

ENDOMETRIO is a comprehensive study that includes ERA, ALICE, EMMA studies and provides an answer about the reproductive health of the patient's endometrium.

All procedures

Women:

Diseases:

Pregnancy management and preimplantation diagnostics

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Why choose IVMED?

A team of experienced professionals

Clinical practice of leading specialists for over 20 years. We have helped more than 10,000 couples become parents. We have experience in solving the most difficult cases of infertility.

Individual programs for everyone

Diagnostic tests, the choice of treatment, medications, programs - everything is adapted to your individual indicators and circumstances.

Legality and complete confidentiality

The clinic operates in compliance with all applicable laws. We guarantee anonymity and medical confidentiality.

Modern genetic laboratory

Cytogenetic and molecular genetic studies from a single gene to the whole genome. Preimplantation genetic diagnosis of 24 embryo chromosomes by NGS (Next Generation Sequencing) with an accuracy of 99.99%.