ENDOMETRIO (ERA+ALICE+EMMA)
Comprehensive study of the functional state of the endometrium to assess the reproductive prognosis.
Analysis of endometrial receptivity, chronic endometritis and endometrial microflora, including ERA, ALICE, EMMA studies.
Indications for ERA
ERA is indicated for patients with repeated failed implantation attempts, as they are at a higher risk of shifting the implantation window.
The purpose of this test is to provide an objective molecular diagnosis of the implantation capacity and reproductive health of the patient's endometrium.
Indications for ALICE
ALICE can be useful for every patient who wants to get pregnant, as it provides an opportunity to assess the microbiological environment that the embryo will encounter during implantation.
ALICE is also recommended for patients with recurrent pregnancy loss and/or repeated implantation failure in history, as this can cause chronic endometritis.
Indications for EMMA
EMMA is a molecular test that provides information about the microbiota in endometrial tissue by analyzing a special panel of bacteria, including information about the most common lactobacillus species and potentially pathogenic bacteria of the reproductive tract (some of which are associated with chronic endometritis). This method is based on the detection of bacterial DNA using real-time PCR (real-time polymerase chain reaction).
Diagnosis of the implantation window period
ERA is an analysis of endometrial receptivity to determine the optimal time for embryo transfer (implantation window period).
ERA can increase the chances of pregnancy by synchronizing a ready-to-implant embryo with a receptive endometrium.
This test uses next-generation sequencing (NGS) technology to analyze the expression of 248 genes associated with endometrial receptivity.
Diagnosis of infectious chronic endometritis
ALICE is an analysis of infectious chronic endometritis that detects the most common bacteria that cause chronic endometritis.
Chronic endometritis is a persistent inflammation of the endometrial mucosa caused by infection of the uterine cavity, mainly by bacterial pathogens. Chronic endometritis is usually asymptomatic, and modern classical diagnostic methods (histology, hysteroscopy, and microbiological culture) are insufficient to establish a diagnosis.
Diagnosis of Chronic Endometritis and Endometrial Microflora
EMMA - analysis of chronic endometritis and endometrial microbiota.
Metagenomic analysis of the endometrial microbiome provides a comprehensive view of the bacterial composition of the endometrium, including pathogens that cause chronic endometritis.
Identification of pathogenic microbiomes may be the key to improving the outcomes of subsequent treatment of chronic endometritis.
Studies have revealed the existence of the endometrial microbiome and demonstrated that uterine dysbiosis is associated with poor reproductive outcomes. This suggests that pathogenic changes in the level of endometrial lactobacilli may play a role in the development of infertility.
EMMA will help determine whether the microbial environment of the uterus is optimal for embryo implantation.
A single biopsy is sufficient for a comprehensive ENDOMETRIO test.
ENDOMETRIO is a comprehensive study that includes ERA, ALICE, EMMA studies and provides an answer about the reproductive health of the patient's endometrium.
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By clicking, you accept the terms and conditions “Consent to the collection and processing of personal data” and “Public agreement on the provision of medical services”
